Best Ergonomic Mouse (Updated 2022)

So, you’ve decided you’ve had enough with the pain that comes along with using a mouse for extended periods of time, or you already have issues with using the mouse and are looking for something to at least help lessen the pain and strain. Luckily you have an option to help relieve that discomfort. What you’re looking for is an ergonomic mouse, but which one is the best ergonomic mouse? If you’ve ever suffered from or might be developing something like carpal tunnel syndrome, then an ergonomic mouse is a must.

Thankfully, there are tons of options out there when it comes to ergonomic mice. Which one you choose will not only depend on the level of ergonomic comfort you desire but also on what other features you find important in a computer mouse. Just because a mouse is ergonomic doesn’t mean it’s not a mouse anymore; it’s just more comfortable to use. To help you with your decision, take a look at our list of the best ergonomic mice and say goodbye to your mouse strain and pain. As you browse this guide, consider the pros and cons of each product. Once you’re finished, you’ll be able to find the best ergonomic mouse for you!

Editors choice

1. Logitech MX Vertical

9.50 / 10

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The benefits of an ergonomic mouse are pretty clear, especially if you’ve suffered from carpal tunnel or used a mouse for extended periods of time. However, functionality has to go along with the benefits. The best ergonomic mouse in the world is useless if you can’t use it the way you want. The Logitech MX Vertical not only has ergonomic benefits but also is very functional.

It’s the holidays, so the MX Vertical sort of reminds me of a Hershey’s Kiss with its 57-degree vertical angle and wave-textured thumb rest area. The “handshake” design offers two right/left-click buttons, a scroll wheel, two forward/back thumb buttons, and a DPI switch button. The buttons are customizable and USB/Bluetooth connectable. A nice feature is that the MX Vertical utilizes Flow control to sync up to three devices. It has a rechargeable battery which has very good lasting power. As with any vertical mouse, it may take a bit of time to get used to the “handshake”’ position coming from a traditional mouse, but the ergonomics of the MX Vertical will make that transition easy, especially when you feel how comfortable it is to use. Add in the fact that it is set up to have the same functionality as a traditional mouse only increases its usefulness; the mouse just works.

The Logitech MX Vertical does an adept job of combining functionality with ergonomics making it a great choice as a computer peripheral. The MX Vertical is a strong contender on the list of best ergonomic mice.

Key Features

  • Wireless ergonomic mouse
  • 57 degree vertical angle
  • 4000 DPI sensor
Specifications

  • Weight: 8.0 ounces
  • Sensor: Optical
  • System Requirements: Windows/Mac
  • Wireless?: Yes
  • Brand: Logitech
Pros

  • Textured surface
  • Rechargeable
  • 3-device switching
  • Customizable
Cons

  • No USB dongle storage
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Premium pick

2. Logitech MX Master 3

9.60 / 10

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Who doesn’t want to be productive? But, when you think about productivity, do you often think of the mouse as a crucial element to help you reach that goal? Maybe not, but the right mouse can absolutely increase your productivity, and if it is ergonomic, not cause damage while doing so. The Logitech MX Master 3 is an outstanding choice as an ergonomic mouse great for productivity.

The MX Master 3 has a sleek if not serious look to its design; this is a mouse all about work. Buttons include the standard right/left-click, scroll wheel, horizontal thumbwheel, two thumb buttons, a gesture control button. All buttons are configurable, including app-specific profiles via the Logitech Options software. The magnetized scroll wheel is great for productivity because of its “free spin” or “ratchet” modes which allow you to select how you scroll through documents and the like. Nice features include Flow multi-computer control and the Darkfield sensor, which tracks quickly and precisely on most flat surfaces. It is rechargeable and has great battery life. Wireless connectivity is via USB dongle or Bluetooth. If the included features help your productivity, the fact that its ergonomic design helps you do so comfortably will send your productivity through the roof.

The Logitech MX Master 3 is a mouse design to help increase your productivity by combining comfort and customizability. This is a serious mouse but usable for just about anyone. The MX Master 3 is a strong entrant on the list of best ergonomic mice.

Key Features

  • Electromagnetic scrolling
  • Intuitive thumb controls
  • Flow control
Specifications

  • Weight: 11.3 ounces
  • Sensor: Darkfield laser
  • System Requirements: Windows/Mac/Linux
  • Wireless?: Yes
  • Brand: Logitech
Pros

  • App-specific profiles
  • Large thumb area
  • Great battery life
Cons

  • No storage slot for USB dongle
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Best value

3. Anker 2.4G

9.00 / 10

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‘Ergonomic’ much like ‘organic’ can far too often be a buzzword for expensive. I will never understand why the things that are good for us are usually cost-prohibitive. When you think about computer peripherals, it may not make too much sense to pay a high price for a mouse, even if it does have some benefits. The Anker 2.4G Vertical Ergonomic Mouse is a value-priced mouse that doesn’t trap you into paying more for something that is good for you.

The Anker 2.4G is a well-built vertical mouse meaning that it is rather tall and designed such that you use it in a ‘handshake’ position. The Anker 2.4G buttons include the typical two-button setup with a scroll wheel in the middle. They are positioned on the side, but once you ‘shake hands’ with it, their placement will feel quite familiar. A DPI button (800/1200/1600) is located near the top. The included USB dongle (there is no Bluetooth connectivity) tucks into the unit when not in use. The Anker 2.4G uses optical tracking technology for use on many different types of surfaces with very good precision. Unfortunately, it is not rechargeable and requires three AAA batteries. Setup is easy with no need for additional software. The vertical nature of the Anker 2.4G and the ergonomically designed thumb rest makes it very comfortable and strain-free to use for extended periods.

The Anker 2.4G makes the case that beneficial features don’t necessarily have to be expensive. Its low price and features make it a solid choice on the list of best ergonomic mice.

Key Features

  • Vertical ergonomic design
  • Optical tracking
  • Five control buttons
Specifications

  • Weight: 3.36 ounces
  • Sensor: Optical
  • System Requirements: Windows/Linux/Mac
  • Wireless?: Yes
  • Brand: Anker
Pros

  • Affordable
  • Compact design in a vertical mouse
  • Sleek design
Cons

  • Does not have a rechargeable battery
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4. ZLOT Vertical Gaming Mouse

9.10 / 10

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When you think about it, an ergonomic mouse just makes sense for gamers. A gamer can’t make life-saving, danger-dodging moves over the extent of a long gaming session if his/her wrist or hand is tired or sore. The ZLOT Vertical Gaming Mouse is an obvious choice as an ergonomic mouse for gamers.

The ZLOT is a vertical mouse featuring a 6+1 design with six buttons that can be easily mapped to in-game functions, plus a mini-joystick with a five-position rocker (that’s 11 buttons in total). Other than the buttons, there are other gamer-centric features, including on-board memory, an exceedingly high DPI max of 10,000, color-changing RGB lighting, as well as game-crushing quick and sensitive response. Those gamer features are only enhanced by the ergonomic features of the ZLOT, which include that natural “handshake” vertical design that keeps the hand, wrist, and arm in a neutral position for a comfortable grip allowing for extended use without the worry of fatigue or pain. The ZLOT is wired, but that is the norm for performance-focused gaming mice. On top of the gaming and ergonomic features of the ZLOT is the fact that it is available at an affordable price which will leave room to get the latest games and crush them.

The ZLOT Vertical Gaming Mouse is packed with features that will make you a gamer to contend with. Its excellent ergonomic features will enhance your gaming abilities and experience. The ZLOT is a great choice among the best ergonomic mice.

Key Features

  • Wired ergonomic vertical mouse
  • 10,000 DPI
  • Integrated joystick
Specifications

  • Weight: 6 ounces
  • Sensor: Optical
  • System Requirements: Windows/Linux
  • Wireless?: No
  • Brand: ZLOT
Pros

  • 11 programmable buttons
  • On-board memory
  • RGB highlights
  • Long cable
Cons

  • Not wireless
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5. Kensington Pro Fit

8.75 / 10

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Combining cool tech features isn’t always a good or welcome idea. Just because you can add wi-fi to something doesn’t mean it will make sense (Juicero, anyone?). When it comes to computer mice, it seems the choices have no sort of combination of the best features of each type. The Kensington Pro Fit Ergo, however, combines the features of a trackball with those of a vertical mouse to make a very unique and very usable mouse.

The Pro Fit Ergo looks sort of like a bloated traditional mouse with its somewhat hefty size, but the red trackball on the side immediately tells you there is nothing traditional about this mouse. It is angled at 60 degrees for that “handshake” design typical of vertical mice. Buttons include the standard right/left-click buttons and a scroll wheel, but there are also five additional buttons, including DPI adjustment, forward/back, and extra buttons that are programmable using the excellent KesiningtonWorks software. You can find all or most of those features on a typical vertical mouse, but the Pro Fit Ergo goes one step further by adding in a trackball which can be popped out easily to clean. Performance with this dual-feature sort of design is great with precision and responsiveness. The Pro Fit Ergo is wireless via a USB dongle and Bluetooth. One downside is that it is not rechargeable and requires two AA batteries.

The Kensington Pro Fit Ergo does a great job of combining great ergonomic mouse features.No need to separately try out a vertical or trackball mouse; this one will work to introduce you to both. The Pro Fit Ergo is an innovative member of the best ergonomic mouse listing.

Key Features

  • 60 degree tilt angle
  • Wireless trackball mouse
  • Same button configuration as traditional mouse
Specifications

  • Weight: 7.05 ounces
  • Sensor: Optical
  • System Requirements: Windows/Mac
  • Wireless?: Yes
  • Brand: Kensington
Pros

  • 9 programmable buttons
  • Connect up to 3 devices
  • Removable trackball
  • KensingtonWorks software
Cons

  • Not rechargeable
  • right-handed only
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6. Logitech MX Ergo

9.15 / 10

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For ergonomics sake, trackballs just make sense because they eliminate repetitive wrist motions, which is helpful in avoiding carpal tunnel. But trackballs are one of those useful oddities that just haven’t become mainstream. The Logitech MX Ergo is an innovative ergonomic mouse that can make the transition from a traditional mouse an easy one.

Looking like a traditional mouse with a trackball slapped onto it, the MX Ergo has a substantial feel about it with its detachable metal base. It is wireless via a USB dongle and also features Bluetooth for connectivity. In addition to the trackball, the customizable buttons include the usual left and right-click buttons, two thumb buttons, a button to switch between USB and Bluetooth connections, a left/right function scroll wheel, and a button for ‘precision mode.’ The Flow feature, which allows control of two computers at once, is a nice capability. The MX Ergo has a rechargeable battery that can last around two months. Ergonomic features of the MX Ergo include its overall ergo-friendly design and the added ability to switch the mouse from flat to raising it to a 20-degree angle. That 20-degree angle allows the hand and arm to rest at a more natural position which, when combined with the fact that the mouse is meant to stay still on your desk, adds to the comfort level when using the MX Ergo.

While using a trackball may not initially feel intuitive, the Logitech MX Ergo will make the transition seamless and easy. Its ergonomic features and customization will not only make using a trackball easy to use but comfortable as well. The MX Ergo is a top entrant on the list of best ergonomic mice.

Key Features

  • USB/Bluetooth wireless connectivity
  • 0-20 degree adjustable hinge
  • Trackball sensor
Specifications

  • Weight: 5.76 ounces
  • Sensor: Trackball
  • System Requirements: Windows/Mac
  • Wireless?: Yes
  • Brand: Logitech
Pros

  • Rechargeable battery
  • 8 customizable buttons
  • USB-C charging
  • Dual connectivity
Cons

  • Right-handed only
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7. Kensington Orbit Trackball Mouse

8.65 / 10

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Even though trackballs are inherently more ergonomic and have been around longer than the ubiquitous mouse design of today, they remain a less popular choice when it comes to computer navigating devices. One reason can be the learning curve which is actually quite low. The Kensington Orbit Trackball with Scroll Ring adds in features that make that learning curve less of a burden, thereby making a trackball an attractive alternative when it comes to ergonomic mice.

Looking sort of like one of the alien spacecraft from “War of the Worlds” (the 1953 version), the Orbit Trackball has a blue trackball atop a smooth-lined body. There are two standard mouse click buttons on either side of the trackball, these are the only two buttons on the Orbit Trackball, but they are customizable. What makes the Orbit Trackball different is that it has a scroll wheel which is a traditional mouse feature that most trackball-style mice struggle with. The scroll wheel extends around the base of the trackball, making finding a comfortable position to use it quite easy. It is not wireless, but that may not be much of an issue considering trackball mice are essential fixed-position peripherals that add to the ergonomic benefits of the mouse. An included wrist rest enhances the ergonomic comfort of the Orbit Trackball. Performance-wise, the Orbit Trackball is responsive and accurate.

Having the scroll wheel and only two buttons make the Kensington Orbit Trackball an attractive proposition as an ergonomic mouse alternative. It lowers the trackball learning curve making it one of the best ergonomic mouse choices available.

Key Features

  • Scroll ring
  • Wired trackball mouse
  • Detachable wrist rest
Specifications

  • Weight: .65 pounds
  • Sensor: Trackball
  • System Requirements: Windows/Mac
  • Wireless?: No
  • Brand: Kensington
Pros

  • Ambidextrous design
  • Kensington TrackballWorks software
  • Two customizable buttons
Cons

  • Small trackball
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8. AmazonBasics Ergonomic Wireless Mouse

8.15 / 10

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It may be hard to believe, but there are other quality mouse manufacturers out there other than Logitech. If you limit yourself to only brand-name products, you could be missing out on other quality products that may be out there. The AmazonBasics Full-size Ergonomic Mouse is an example of a great ergonomic mouse made by someone other than Logitech.

The AmazonBasics Ergonomic Mouse is a full-size yet compact wireless mouse that has the same basic look and features found on much more expensive options. Buttons include the standard right/left-click buttons, forward/back buttons, a clickable scroll wheel, and a DPI adjustment button. Connectivity is via a USB dongle only as there is no Bluetooth. Tracking is smooth and precise and works on just about any flat surface. The downsides include that it is not rechargeable, and the buttons are not programmable. However, the AmazonBasics Ergonomic Mouse fits nicely in hand with its rubberized sides and nicely curved contours for comfortable use. There is also a curved area that provides an area to rest your thumb. Being full-sized, it is more suited to medium to large-sized hands, but those with professed tiny hands will have no problem using this mouse.

The AmazonBasics Ergonomic Mouse may not have the recognition of the big boys in the mouse world, but as a straightforward, ergonomic mouse, it holds its own quite well. Add in a non-bank-breaking price point, and this ergonomic mouse is even more attractive. The AmazonBasics Ergonomic Mouse is a great choice from the listing of the best ergonomic mice.

Key Features

  • Full-size wireless mouse
  • Fast scrolling
  • Adjustable DPI
Specifications

  • Weight: 5.12 ounces
  • Sensor: Optical
  • System Requirements: Windows
  • Wireless?: Yes
  • Brand: AmazonBasics
Pros

  • Affordable
  • Plug and play
  • Back and forward thumb buttons
  • Works on most surfaces
Cons

  • Not rechargeable
  • No Bluetooth
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9. Microsoft Sculpt Ergonomic Mouse

8.00 / 10

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It isn’t actually necessary for an ergonomic mouse to be extravagant with tons of buttons and weird-looking designs. Sometimes the simpler something is, the better it actually works. The Microsoft Sculpt Ergonomic Mouse using a minimalist design to effectively offer the same ergonomic features found on more fancy models.

The Sculpt looks like a raindrop with its rather rotund appearance. There is nothing extravagant about this mouse as it has only the standard right/left-click buttons flanking a four-way scroll wheel and a back button. The only extra with the Sculpt is a dedicated Windows button for quick access to the start menu on windows setups. Tracking comes via what Microsoft calls BlueTrack Technology, offering fast and precise tracking. The Sculpt is a mouse more interested in providing comfort, as is clearly evidenced by its design. The height and slight angle of the Sculpt provide great palm support to reduce strain and increase comfort. It also has a thumb scoop for resting your thumb and keeping your hand in the proper position adding to the overall comfort of using the Sculpt. A potential downside is that it is not rechargeable.

The Microsoft Sculpt Ergonomic Mouse makes minimalist design work and looks just as good as over-the-top offerings from other mouse manufacturers. The Sculpt reminds us that a computer mouse is a simple thing that just needs to do what you want to do, hopefully without causing discomfort. Being simple to use and ergonomic makes the Sculpt a great choice from the list of the best ergonomic mice.

Key Features

  • Wireless ergonomic mouse
  • Windows button
  • Thumb scoop
Specifications

  • Weight: 6.86 ounces
  • Sensor: Blue Track
  • System Requirements: Windows/Mac
  • Wireless?: Yes
  • Brand: Microsoft
Pros

  • 4-way scroll wheel
  • Back button
  • Solid design
  • Tracks on most surfaces
Cons

  • Not rechargeable
  • Cannot be paired with multiple devices
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10. Swiftpoint GT

7.50 / 10

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Calling a computer mouse mobile can be considered a redundant statement, but when you think about it, not all mice are designed to be carried along with you wherever you go. This is especially the case with ergonomic mice, which can be somewhat hefty when compared to traditional mice. The Swiftpoint GT is a mouse that combines both the convenience of mobility and also the added bonus of being very ergonomic.

The first thing you notice about the Swiftpoint GT is that it doesn’t really look like a mouse. More reminiscent of those blood oxygen monitoring thingies nurses put on your finger, and not much bigger. In fact, it is small enough to be used directly on your laptop next to the trackpad. The Swiftpoint GT is a wireless ergonomic mouse that you hold between your thumb and middle finger, much like holding a pen. Its shape is innovative, allowing for comfortable use. It has left and right-click buttons that are easily accessible with your index finger. Near the front is a scroll wheel. The Swiftpoint GT is USB and Bluetooth connectable. A neat feature is that the unit magnetically attaches to the USB dongle while charging. The Swiftpoint GT operates like a traditional mouse, but it also utilizes gesture control which sends the same sort of signals to touch screens as your fingers would.

To say the Swiftpoint GT is innovative would be an understatement. Simply put, Swiftpoint GT is one of the best on the listing of best ergonomic mice.

Key Features

  • Wireless ergonomic mouse
  • Pen-like grip
  • Touch gesture technology
Specifications

  • Weight: 0.8 ounces
  • Sensor: Optical
  • System Requirements: Windows/Mac/Linux
  • Wireless?: Yes
  • Brand: Swiftpoint
Pros

  • Compact design
  • Rechargeable
  • USB charger/receiver
  • Large scroll wheel
Cons

  • Expensive
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Considering the length of time we use computers and the actual physical movements needed to do so, it is a wonder that more people don’t put more consideration into the type of mouse used. Sure, there are ergonomic chairs, desks, and keyboards, but what about the mouse, the thing you probably interact with more on a regular basis. Dismissal of the importance of ergonomics in the computing age, and especially mouse use can lead to some very debilitating health conditions.

Factors To Consider When Buying An Ergonomic Mouse

One of the main culprits when it comes to the dangers of using a mouse is repetitive strain injury or the dreaded Carpal tunnel syndrome. According to the Mayo Clinic, Carpal tunnel syndrome is caused by pressure on the median nerve which can cause numbness, tingling, and weakness in the hand and arm. You may think that a little thing like a mouse couldn’t possibly cause problems, but overuse resulting in a strain of your hands and wrist from using a mouse can cause Carpal tunnel. Believe me, as someone who has had Carpal tunnel syndrome severe enough to need surgery to fix it, having it is a nightmare. Had I used an ergonomic mouse through the years, I would not have had to go down that road.

There are different types of ergonomic mice to choose from. There is the so-called horizontal ergonomic mouse which looks a lot like a traditional mouse but has a contoured shape to increase comfort in using it. Next is the ergonomic vertical mouse which puts your hand in a natural sort of “handshake” position to hold it thereby reducing the need for constant wrist movement. Lastly, there is the trackball mouse which doesn’t require any wrist or arm movement. Each ergonomic mouse configuration has its benefits and minuses, all of which will depend on user preference. If you prefer a more traditional mouse with ergonomic features, the horizontal mouse may be more suitable for you. Unlike the horizontal ergonomic mouse, the vertical mouse and trackball may take some getting used to, but their ergonomic benefits might be more effective. Space will also have to be a consideration. The horizontal and vertical ergonomic mouse will require some space on your desktop to be used whereas the trackball mouse is a “static” sort of mouse meaning it doesn’t need to be moved around on your desktop.

Aside from the ergonomic make-up of the mouse, you will also have to consider the typical mouse functionalities you will want. You will find that most ergonomic mice will have the same features as traditional mice including being wireless, having rechargeable batteries, optical tracking, customizable buttons, etc.

There are certainly a ton of choices out there when it comes to finding an ergonomic mouse. To help out, here’s a listing of the best ergonomic mice out there today. Before you know it, you’ll be using a mouse with no worries about the possible damage being done.

FAQ

Q: What makes a mouse ergonomic?

Unlike a traditional mouse, an ergonomic mouse is designed with the health and comfort of the user in mind. A traditional mouse requires the hand to be in an unnatural position thereby placing stress on the muscles and tendons of the hand. An ergonomic mouse reduces that stress by placing the hands, as well as the wrists, elbows, and arms in a more natural position. Using a mouse in a more natural position will help prevent fatigue and injury. Its design features allow these mice to incorporate the five aspects of ergonomics, which are: comfort, safety, ease of use, productivity/performance, and aesthetics.

Q: Are ergonomic mice hard to use?

There can be a period of adjustment going from a traditional mouse to an ergonomic one. Though an ergonomic mouse will generally have the same buttons in more or less the same positions as a traditional mouse, in some ways, you will have to retrain yourself in using an ergonomic mouse. As with learning anything new, all that’s needed in adjusting to an ergonomic mouse is training, practice, and patience. However, given the more natural approach that an ergonomic mouse encourages, any adjustment period will usually be short as you get more comfortable in using an ergonomic mouse.

Q: What are the different types of ergonomic mice?

There are essentially five types of ergonomic mice. There’s the familiar standard, vertical and trackball style of ergonomic mouse and the possibly lesser-known ergonomic pen and joystick configurations. A standard (or horizontal) mouse looks very much like a traditional mouse only it features an ergonomic shape. A vertical mouse has you place your hand in a vertical or handshake type of position. With a trackball mouse, the base is stationary and the mouse is controlled by rolling a ball. An ergonomic pen mouse is designed to be held like a pen or pencil. The ergonomic joystick mouse also incorporates a handshake position with your hand set vertically to control the mouse.

Q: Does hand size make a difference when choosing an ergonomic mouse?

When it comes to ergonomics, there is no ‘one size fits all.’ Even with an ergonomic mouse, if it does not fit your hand you could still experience pain and fatigue especially if you have to constantly “claw” (mouse too small) or “shuffle” (mouse too large) your hand to use it. To get the best fit, you will have to measure your hand and select a mouse that suits it. Most manufacturer sites have sizing guides but generally, sizes are broken down into small for a hand size of under 6.75 inches (17cm), medium 6.75 to 7.5 inches (17-19 cm), large 7.5 to 8.35 inches (19-21 cm), and extra-large 8.25 inches and over (21 cm or larger).

Q: What conditions can develop from not using an ergonomic mouse?

Because a traditional mouse forces you to move your hand, wrist, and arm in ways that are unnatural and uncomfortable, their use can lead to painful, unhealthy conditions. The conditions that can develop include mouse arm syndrome which is a broad category that includes carpel tunnel syndrome and repetitive stress injury (RSI) among other conditions that can lead to pain in the hand, wrist, forearm, elbow, neck, and shoulder. An ergonomic mouse can help prevent the aggravation of existing pain (like arthritis) and reduce the risk of developing mouse arm syndrome. Another benefit is that an ergonomic mouse can also help to alleviate fatigue.

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